2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140154
    Methylamino-PEG1-Boc 1807521-03-4
    Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methylamino-PEG1-Boc
  • HY-122459
    Fmoc-PEG5-NHS ester 1402080-11-8 ≥98.0%
    Fmoc-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG5-NHS ester
  • HY-130829
    m-PEG15-NHS ester 98.0%
    m-PEG15-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG15-NHS ester
  • HY-141084
    Fluorescein-PEG6-bis-NHS ester 2055105-59-2
    Fluorescein-PEG6-bis-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fluorescein-PEG6-bis-NHS ester
  • HY-134512A
    Aminooxy-PEG3-C2-thiol hydrochloride 98.0%
    Aminooxy-PEG3-C2-thiol (hydrochloride) is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
    Aminooxy-PEG3-C2-thiol hydrochloride
  • HY-133374
    DBCO-PEG12-Maleimide 98.0%
    DBCO-PEG12-Maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG12-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG12-Maleimide
  • HY-130662
    Hydroxy-PEG8-Boc 1334177-84-2 98.0%
    Hydroxy-PEG8-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Hydroxy-PEG8-Boc
  • HY-138740
    Azido-PEG2-propargyl 1245006-63-6
    Azido-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-propargyl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-propargyl
  • HY-140815
    Azido-PEG8-hydrazide 2353410-11-2
    Azido-PEG8-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-hydrazide
  • HY-138446
    Amino-PEG4-C2-SH hydrochloride
    Amino-PEG4-C2-SH hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG4-C2-SH hydrochloride
  • HY-140565
    N-(Azido-PEG3)-N-Boc-PEG4-Boc 2112731-94-7
    N-(Azido-PEG3)-N-Boc-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-Boc-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-Boc-PEG4-Boc
  • HY-140519
    N-(Azido-PEG4)-N-bis(PEG4-acid) 2093152-80-6
    N-(Azido-PEG4)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG4)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG4)-N-bis(PEG4-acid)
  • HY-W190968
    Cbz-PEG2-bromide 2100283-00-7
    Cbz-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-PEG2-bromide
  • HY-133480
    Bromoacetyl-PEG3-DBCO 98.62%
    Bromoacetyl-PEG3-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetyl-PEG3-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Bromoacetyl-PEG3-DBCO
  • HY-W190963
    Boc-NH-PEG7-acetic acid 141282-29-3 98.0%
    Boc-NH-PEG7-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG7-acetic acid
  • HY-133381
    DSPE-PEG36-DBCO
    DSPE-PEG36-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DSPE-PEG36-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DSPE-PEG36-DBCO
  • HY-130188
    Benzyl-PEG2-azide 1260001-87-3 99.12%
    Benzyl-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Benzyl-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Benzyl-PEG2-azide
  • HY-140896
    Biotin-PEG5-amine 113072-75-6 99.25%
    Biotin-PEG5-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG5-amine
  • HY-138358
    Azido-PEG23-C2-azide
    Azido-PEG23-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG23-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG23-C2-azide
  • HY-133476
    TCO-PEG3-alcohol 1955497-82-1 99.32%
    TCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-PEG3-alcohol is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-PEG3-alcohol
PROTAC Linkers Isoform Comparison

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